Asmodeus, the Fallen Angel of Lust, has escaped Hell and is now on earth in the form of a beautiful and sultry woman named Autumn Blaze, a mesmerizing prostitute who possesses a huge appetite for sex. In order to avoid The Ache, a berserker-like condition that results in a murderous rampage, she must have sex every forty-eight hours. Residing in Las Vegas, she has managed to stay off the radars of both Heaven and Hell. However, when a client's actions result in his death, Autumn will soon find that Hell is alive and well on earth and she is standing on ground zero.